Mutagenic activity of phthalate esters in bacterial liquid suspension assays.
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منابع مشابه
Mutagenic activity of phthalate esters in bacterial liquid suspension assays.
The mutagenic activities of several phthalate esters have been evaluated in an 8-azaguanine resistance assay in Salmonella typhimurium. Three phthalate esters were found to be mutagenic: dimethyl phthalate, diethyl phthalate and di-n-butyl phthalate. A number of other phthalate esters were not found to be mutagenic, including di(2-ethylhexyl) phthalate, di-n-octyl phthalate, diallyl phthalate, ...
متن کاملGenetic toxicology of phthalate esters: mutagenic and other genotoxic effects.
The effects of DEHP on sperm morphology and on peripheral blood micronuclei were studied for 12 weeks following five subacute IP injections of DEHP at 1/6, 1/12, and 1/60 of the LD50 per day. Sperm morphology was examined in both adult mice and rats, while peripheral blood micronuclei were scored in mice up to 4 weeks after treatment. In mice, DEHP at 1/6 LD50 significantly depressed body weigh...
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A large number of phthalate esters were screened for estrogenic activity using a recombinant yeast screen. a selection of these was also tested for mitogenic effect on estrogen-responsive human breast cancer cells. A small number of the commercially available phthalates tested showed extremely weak estrogenic activity. The relative potencies of these descended in the order butyl benzyl phthalat...
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The American Chemistry Council Phthalate Esters Panel read with great interest the paper by Blount et al. (1) regarding urinary levels of phthalate ester metabolites in a sample set of the Third National Health and Nutrition Examination Survey (NHANES III) population. We have known for some time of this research, and have provided whatever information and assistance we could to the Centers for ...
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The testicular effects produced by di(2-ethylhexyl) phthalate (DEHP) in the rat, characterized by a decrease in the relative organ weight and histological changes in the seminiferous tubules, can also be produced by di-n-butyl, di-n-pentyl and di-n-hexyl phthalates. The corresponding monoesters of these compounds, formed in vivo as a result of the action of nonspecific esterases in the intestin...
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 1982
ISSN: 0091-6765,1552-9924
DOI: 10.1289/ehp.8245111